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SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Milk Thistle extract (seed) standardized to 80% silymarin (140 mg)
175 mg
**
Top Medical Research Studies
9
Silybin shows promise for autoimmune disorders
Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation.
High potential therapeutic relevance
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows immunosuppressive effects
Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.
Potential treatment for autoimmune disorders.
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
9
Silibinin shows promise in autoimmunity
The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis.
Moderately relevant to autoimmune therapy
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
Most Useful Reviews
9.5
Liver enzyme improvement
V.E. Thiessen (retired businessman) found this product to achieve what no prescription could for my wife. She has an autoimmune disorder and has undergone a liver transplant, with persistent high liver enzymes. Since using milk thistle, we've seen them return to normal, much to the transplant team's surprise. Thisilyn, supplied by iHerb, is our preferred choice. The service is always quick and reliable.
Read More
9.5
Improve digestion
Following my doctor’s advice, I ordered this product to enhance my gastrointestinal function alongside other liver and bile treatments. After just a week, my digestive system has improved significantly, with better regularity and reduced liver colic pain. I plan to complete the full course for even greater results.
Read More
8.3
Ongoing improvement
I continue to order Nature's Way Milk Thistle for my liver health, and I'm observing marked improvement in my condition.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
9
Silybin shows promise for autoimmune disorders
Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation.
High potential therapeutic relevance
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows promise in autoimmunity
The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis.
Moderately relevant to autoimmune therapy
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
9
Silymarin boosts insulin production
Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model.
Highly relevant diabetes treatment insight
We analyzed how Silymarin affects the Pdx1 gene expression and insulin production in a model of diabetes following partial pancreatic removal. With 72 rats divided into groups, those treated with Silymarin showed significant increases in both Pdx1 and insulin levels compared to untreated rats.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Read More
9
Silibinin shows immunosuppressive effects
Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.
Potential treatment for autoimmune disorders.
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
8
Silymarin shows promise for MS
Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß-Treated MS Patients.
Relevant findings for immune modulation.
We explored the impact of silymarin, a compound from milk thistle, on the immune system in patients with multiple sclerosis (MS). By isolating Th1 cells from both newly diagnosed and treatment-receiving patients, we assessed how silymarin affected cell activity at various doses and times.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
9.5
Liver enzyme improvement
V.E. Thiessen (retired businessman) found this product to achieve what no prescription could for my wife. She has an autoimmune disorder and has undergone a liver transplant, with persistent high liver enzymes. Since using milk thistle, we've seen them return to normal, much to the transplant team's surprise. Thisilyn, supplied by iHerb, is our preferred choice. The service is always quick and reliable.
Read More
9.5
Improve digestion
Following my doctor’s advice, I ordered this product to enhance my gastrointestinal function alongside other liver and bile treatments. After just a week, my digestive system has improved significantly, with better regularity and reduced liver colic pain. I plan to complete the full course for even greater results.
Read More
8.8
Effective liver nutrition
I recently ordered milk thistle again after positive effects last month. It helps boost my liver health, making me feel less fatigued. I have not experienced hangovers while taking it and plan to continue this liver nutrition monthly. I have returned for a second order, as it was a great choice for my health.
Read More
8.8
Relief from pain
I recently switched from regular milk thistle to Nature's Way Thisilyn and have found it’s effective for relieving liver pain related to my autoimmune disorder. So far, it seems to be working well, and I've ordered more to continue the benefits.
8.8
Consistent bowel movements
I ordered this milk thistle supplement during pregnancy and have continued taking it since. It has regulated my bowel movements hourly without nausea. The benefits of milk thistle are often underestimated, and I highly recommend it.
