Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
USERS' SCORE
Good
Based on 7 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Milk Thistle extract (seed) standardized to 80% silymarin (140 mg)
175 mg
**
Top Medical Research Studies
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows immunosuppressive effects
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
9
Silibinin shows promise in autoimmunity
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
Most Useful Reviews
9
Liver enzyme improvement
24 people found this helpful
V.E. Thiessen (retired businessman) found this product to achieve what no prescription could for my wife. She has an autoimmune disorder and has undergone a liver transplant, with persistent high liver enzymes. Since using milk thistle, we've seen them return to normal, much to the transplant team's surprise. Thisilyn, supplied by iHerb, is our preferred choice. The service is always quick and reliable.
Read More
9
Improve digestion
1 people found this helpful
Following my doctor’s advice, I ordered this product to enhance my gastrointestinal function alongside other liver and bile treatments. After just a week, my digestive system has improved significantly, with better regularity and reduced liver colic pain. I plan to complete the full course for even greater results.
Read More
9
Ongoing improvement
I continue to order Nature's Way Milk Thistle for my liver health, and I'm observing marked improvement in my condition.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
- All Researches
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows promise in autoimmunity
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
9
We analyzed how Silymarin affects the Pdx1 gene expression and insulin production in a model of diabetes following partial pancreatic removal. With 72 rats divided into groups, those treated with Silymarin showed significant increases in both Pdx1 and insulin levels compared to untreated rats.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Read More
9
Silibinin shows immunosuppressive effects
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
8
Silymarin shows promise for MS
We explored the impact of silymarin, a compound from milk thistle, on the immune system in patients with multiple sclerosis (MS). By isolating Th1 cells from both newly diagnosed and treatment-receiving patients, we assessed how silymarin affected cell activity at various doses and times.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Liver enzyme improvement
24 people found this helpful
V.E. Thiessen (retired businessman) found this product to achieve what no prescription could for my wife. She has an autoimmune disorder and has undergone a liver transplant, with persistent high liver enzymes. Since using milk thistle, we've seen them return to normal, much to the transplant team's surprise. Thisilyn, supplied by iHerb, is our preferred choice. The service is always quick and reliable.
Read More
9
Improve digestion
1 people found this helpful
Following my doctor’s advice, I ordered this product to enhance my gastrointestinal function alongside other liver and bile treatments. After just a week, my digestive system has improved significantly, with better regularity and reduced liver colic pain. I plan to complete the full course for even greater results.
Read More
9
Ongoing improvement
I continue to order Nature's Way Milk Thistle for my liver health, and I'm observing marked improvement in my condition.
Read More
7.5
Effective liver nutrition
9 people found this helpful
I recently ordered milk thistle again after positive effects last month. It helps boost my liver health, making me feel less fatigued. I have not experienced hangovers while taking it and plan to continue this liver nutrition monthly. I have returned for a second order, as it was a great choice for my health.
Read More
7.5
Relief from pain
3 people found this helpful
I recently switched from regular milk thistle to Nature's Way Thisilyn and have found it’s effective for relieving liver pain related to my autoimmune disorder. So far, it seems to be working well, and I've ordered more to continue the benefits.
Read More
Frequently Asked Questions
9
Improve digestion
1 people found this helpful
Following my doctor’s advice, I ordered this product to enhance my gastrointestinal function alongside other liver and bile treatments. After just a week, my digestive system has improved significantly, with better regularity and reduced liver colic pain. I plan to complete the full course for even greater results.
9
Ongoing improvement
I continue to order Nature's Way Milk Thistle for my liver health, and I'm observing marked improvement in my condition.
7.5
Repeated effectiveness
1 people found this helpful
I just ordered milk thistle again. I had used it previously and noticed significant effects, particularly in relieving the fatigue associated with my autoimmune disorder. I'm hopeful for the same results with my new order.
9
Liver enzyme improvement
24 people found this helpful
V.E. Thiessen (retired businessman) found this product to achieve what no prescription could for my wife. She has an autoimmune disorder and has undergone a liver transplant, with persistent high liver enzymes. Since using milk thistle, we've seen them return to normal, much to the transplant team's surprise. Thisilyn, supplied by iHerb, is our preferred choice. The service is always quick and reliable.
7.5
Relief from pain
3 people found this helpful
I recently switched from regular milk thistle to Nature's Way Thisilyn and have found it’s effective for relieving liver pain related to my autoimmune disorder. So far, it seems to be working well, and I've ordered more to continue the benefits.
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
8
In our research, we examined the effects of silymarin (Livergol®) on rheumatoid arthritis (RA) in a small group of 44 stable patients. After 90 days of treatment, we noticed a significant decrease in the Disease Activity Score (DAS-28), which assesses inflammation levels. Specifically, patients reported improvement in their symptoms, suggesting potential anti-inflammatory benefits from silymarin due to its antioxidant properties. However, the exact ways it works remain unclear, highlighting the need for more extensive studies with cytokine measurement to unravel its mechanisms further.
9
Silibinin shows promise in autoimmunity
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
9
Silibinin shows immunosuppressive effects
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
7
Potential benefits but limited studies
We investigated how silymarin and its active ingredient, silibinin, can affect symptoms of rheumatoid arthritis (RA) and osteoarthritis (OA). Using a systematic review approach, we sifted through 437 studies, finally focusing on 21 relevant ones.
Our findings revealed that these compounds show impressive properties, such as reducing inflammation and pain and protecting joint health. However, we also noted that while the experimental evidence is promising, further clinical studies are crucial to confirm these benefits and guide effective treatment strategies.
Our findings revealed that these compounds show impressive properties, such as reducing inflammation and pain and protecting joint health. However, we also noted that while the experimental evidence is promising, further clinical studies are crucial to confirm these benefits and guide effective treatment strategies.
References
- Ghahfarrokhi SH, Heidari-Soureshjani S, Sherwin CMT, Azadegan-Dehkordi Z. Efficacy and Mechanisms of , Silymarin, and Silibinin on Rheumatoid Arthritis and Osteoarthritis Symptoms: A Systematic Review. Curr Rheumatol Rev. 2024;20:414. doi:10.2174/0115733971266397231122080247
- Yang HL, Shi XW. Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation. Front Neurol. 2021;12:659678. doi:10.3389/fneur.2021.659678
- Ghiasian M, Nafisi H, Ranjbar A, Mohammadi Y, Ataei S. Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis: A clinical trial study. J Biochem Mol Toxicol. 2021;35:e22800. doi:10.1002/jbt.22800
- Navabi F, Shaygannejad V, Abbasirad F, Vaez E, Hosseininasab F, et al. Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß-Treated MS Patients. Inflammation. 2019;42:54. doi:10.1007/s10753-018-0872-x
- Dupuis ML, Conti F, Maselli A, Pagano MT, Ruggieri A, et al. The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis. Front Immunol. 2018;9:1903. doi:10.3389/fimmu.2018.01903
- Shavandi M, Moini A, Shakiba Y, Mashkorinia A, Dehghani M, et al. Silymarin (Livergol®) Decreases Disease Activity Score in Patients with Rheumatoid Arthritis: A Non-randomized Single-arm Clinical Trial. Iran J Allergy Asthma Immunol. 2017;16:99.
- Soto C, Raya L, Juárez J, Pérez J, González I. Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model. Phytomedicine. 2014;21:233. doi:10.1016/j.phymed.2013.09.008
- Gharagozloo M, Javid EN, Rezaei A, Mousavizadeh K. Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: therapeutic implications for autoimmune diseases. Basic Clin Pharmacol Toxicol. 2013;112:251. doi:10.1111/bcpt.12032
- Min K, Yoon WK, Kim SK, Kim BH. Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis. Arch Pharm Res. 2007;30:1265.
